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FDA approval Phase 1, 2 and 3 clinical trials require companies to perform extensive clinical studies to determine drug safety and efficacy

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Studies have shown that endoplasmic reticulum (ER)-associated molecular chaperone, HSPA5, binds to the GPX4 protein and prevents its degradation to inhibit ferroptosis

Gastroenterology 165 , 515516 (2023)

Depressed participants were excluded for presence of the following: bipolar disorders, psychotic symptoms, history of psychosis outside of a mood episode, any eating disorder or post-traumatic stress disorder (PTSD) within one month of entering the study, and substance abuse or dependence (including alcohol) within six months of entering the study